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Metal-triggered structural transformations, aggregation, and fibrillation of human -synuclein: a possible molecular link between parkinsons disease and heavy metal exposure

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Apart from mutations, other significant factors accounting for -synuclein fibrillation are changes in pH of the microenvironment (Frey et al., 2024), presence of other metal ions temperature (Puspita et al., 2017), phosphorylation (Ghanem et al., 2022