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We received some public comments on the proposed OPPS APC and SI assignments for the new Level II HCPCS codes that were effective on April 1, 2025

Safety and Side Effects of Methylcobalamin and Adenosylcobalamin Side Effects and Safety Common Side Effects (mild to moderate) : Mild headache Nausea or upset stomach Skin rash or itching Rare Side Effects (moderate to severe) : Anxiety or nervousness Chest pain or shortness of breath Hypersensitivity reactions (e.g., swelling, severe rash) Safety Summary : Methylcobalamin is generally well-tolerated when taken as directed