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Thus, the concentration of HGF in serum may be a potential predictive marker for sorafenib efficacy (Shao et al., 2015) and the combination of HGF and c-Met inhibitors and sorefenib could improve the efficacy of the first line systemic treatment (Goyal et al., 2013

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As expected, the addition of the dimeric macrocycles produced a slower migrating band compared with the band of monomeric Met, indicating that the cross-linked Met dimer was formed (Fig