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[DOI] [PubMed] [Google Scholar] 59.Guimares, A

We showed that cirrhotic (an IGF-1 deficiency condition) rats had diminished amino acid and glucose intestinal absorption [114, 194, 195] and that IGF-1 replacement therapy was able to restore both alterations, suggesting a role of IGF-1 in the position of transporters [196]

Given the defects in TCA cycle activity upon FH loss [41], future treatments could also target the broad metabolic changes

found downregulation of oxidative stress and neuronal death after injection of the phenolic substance geraniin by the middle cerebral artery occlusion-reperfusion (MCAO/R), and OGD/R models, as well as by neurological scoring assays, CCK8 assessment, TUNEL staining, detection of cells by flow cytometry, and Western blotting assessment ( ex vivo and in vivo Nrf2, HO-1 protein expression in a concentration-dependent manner in the tMCAO model (Chumboatong et al., 2020)