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In a recent double-blind, randomized, placebo-controlled trial in women with abnormal mammograms, two-to-eight week consumption of about 250 mg/day of broccoli seed extract (~220 mg of glucoraphanin/day) before surgery failed to affect the expression of markers of proliferation and gene expression, including ki-67, p21, HDACs, and acetylated histones, in breast tissues collected after surgery (62)

These compounds exert antioxidative effects by upregulating endogenous antioxidant systems Nrf2/ARE pathway, attenuate neuroinflammation by inhibiting NFB, and interfere with amyloid fibril formation and tau phosphorylation

doi: 10.21037/tcr-2025-128 110 RoperSJCoyleB