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Quick Answer for Lumbago with Sciatica: What it is: Lower back pain (lumbago) plus sciatic nerve irritation causing leg pain Key symptoms: Sharp, burning pain from back to toe, numbness, tingling, weakness Common causes: Herniated disc, spinal stenosis, bone spurs, muscle spasms Treatment options: Conservative care (90% improve within 4 months), physical therapy, medications, injections, surgery if needed When to worry: Leg weakness, loss of bladder/bowel control, severe progressive pain Unlike simple back pain that stays in your lower back, lumbago with sciatica creates a distinctive pattern

Garca-Fernndez M, Castilla-Cortzar I, Daz-Sanchez M et al (2005b) Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis

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Nature 444 , 633637 (2006)