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10.14719/pst.2021.8.2.969 111 TannaI

Clinical pathology of the Jarisch-Herxheimer reaction

one or more amino acid substitutions may be made within the framework regions, and, preferably, the amino acid substitutions improve binding of the antibody to its antigen

In this case, ferroptosis is activated due to iron overload disorder induced by frequent excessive alcohol consumption, generating a large quantity of iron-dependent ROS (148)