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The detailed methodological framework is presented in Figure 1

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Introduction The liver has a central role in metabolism, because of both its anatomic placement and its many biochemical functions The liver receives venous blood from the intestine: thus all of the products of digestion, ingested drugs and other xenobiotics reach it and may be further metabolized before entering the systemic circulation

Some interfere with nutrient absorption, others enhance nutrient excretion and still others impede the body's ability to synthesize nutrients or convert them to useable forms