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PubMed article on regenerative and protective actions of GHK-Cu

Some experimental results suggest significant increases in circulating IGF-1, which is thought to act as a downstream mediator of growth hormone activity

In imiquimod-induced mouse models, betulin-loaded NLCs produced marked lesion improvement accompanied by reductions in systemic inflammatory cytokines such as TNF-, IL-6, and IL-17, along with a lowered spleen index, indicating that their therapeutic benefit extends beyond local skin improvement to systemic immunomodulation [123, 124]

In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy