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With this in mind, it is not surprising that NAM is commonly used to blunt sirtuin or ARTD activities, either in cultured cell assays or in lysis buffers

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doi:10.1007/s00441019030168

Selenium functions as an antioxidant through the activity of selenoproteins Although the importance of Se to health is not fully understood, one well-characterised function of Se is its ability to mitigate oxidative stress through antioxidant-functioning selenoproteins (Table 1), including the well-studied glutathione peroxidase (GPx) and thioredoxin reductase (TrxR) families ( Reference Hamilton and Tappel 18 , Reference Sordillo and Aitken 19 )