465,466 Nevertheless, CRS and ICANS have emerged as significant obstacles impeding the broader application of CAR-T cell therapy in cancer treatment, marked by hyperactivation of the immune system and elevated levels of serum cytokines and pro-inflammatory molecules linked to the proliferation of CAR-T cells (Table 5)
LEARN FROM THE RESEARCHERS RESHAPING THE FIELD Featuring presentations from internationally respected researchers and clinicians including: Dr David Perlmutter Associate Professor Tommy Wood Professor Karl Herrup Dr William Grant Professor Robert Lustig Professor Stephen Cunnane Professor William Harris Professor Joshua Miller Professor Jeremy Spencer Professor Peter Garrard Professor Jonathan Stone Dr Greg Potter Dr Deborah Gordon Associate Professor Simon Dyall Associate Professor David Vauzour Patrick Holford Dr Konrad Kowalski Together, these presentations explore the emerging mechanisms influencing how the brain ages, adapts and degenerates
doi: 10.1021/jacs.3c00841 71 ZhangJGaoBYeBSunZQianZYuLet al
Ultimately, it seems as though injury to the NMJ is a culmination of mutant protein aggregation at the presynaptic nerve terminal, presynaptic cholinergic dysfunction, impaired axonal transport, reduced synaptic acetylcholinesterase, and diseased muscle itself, among others [292]