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These sex-related differences in plasma lipoproteins start to be evident during puberty, in concomitance with the increase in testosterone in males and estrogens in females (Figure 1) ( Estrogens increased ApoA-I expression in the liver and HDL-C levels in pre-menopausal women by modulating the expression of SR-BI and hepatic lipase (Figure 1) ( Differences in lipid profile have also been associated with sex-specific gene expression profile

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