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Pyroptosis is a highly inflammatory form of cell death that can be abnormally activated by oxidative stress, endoplasmic reticulum stress, and pro-inflammatory cytokines, thereby impairing ovarian function

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However, XO-derived RS production is increased in tissues affected by certain diseases, including atherosclerosis (Nasi et al., 2021), rheumatoid arthritis (Hanachi et al., 2009), or Dupuytrens contracture (Murrell and Hooper, 1992)

One of the most common forms of severe acne is nodular acne, which manifests as swollen, red, inflamed, and painful bumps that form on the surface of the skin