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In yet another embodiment, the agent that down-regulates the copy number, amount, and/or activity of at least one target listed in table 1 and/or table 2 comprises an antibody and/or an intracellular antibody or antigen-binding fragment thereof that specifically binds to at least one target listed in table 1 and/or table 2

Main First identified by Albert Claude in 1945 1 , the endoplasmic reticulum (ER) was later defined by George Palade through electron microscopy as a highly specialized membrane-bound organelle essential for the synthesis, folding, and maturation of secretory and membrane proteins 2

Currently, the timing and amount of albumin infusion remain a matter of debate

[DOI] [PMC free article] [PubMed] [Google Scholar] 336.Planty-Bonjour A, Dubory A, Terrier LM, Taibi T, Cook AR, et al