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Methods : A systematic review of the literature was performed in alignment with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)

We found that the deficiency of deglutamylases CCP1 or CCP5 leads to a highly reduced and diffused signal of LCA5, suggesting that the bulge region is lost, thus preventing membrane disc formation and presumably causing photoreceptor death (Figs

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The evidence indicates that ferroptosis is closely related to the pathological process of RP