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Its extreme short half-life (minutes) means intranasal or oral routes without modification are ineffective due to rapid degradation

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characteristic of intrahepatic cholestasis of pregnancy Hepatomegaly / splenomegaly hepatosplenomegaly suggests hemolytic anemia or portal hypertension Neonatal-specific: poor feeding, lethargy, high-pitched cry, hypotonia early warning signs of acute bilirubin encephalopathy

In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis