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Ferroptosis and necroptosis thus form a self-amplifying, reciprocal loop mediated by ROS, RIPK3, and lipid peroxidation in ocular diseases, with RIPK3 serving as the molecular intersection (146)

Apoptosis: Its origin, history, maintenance and the medical implications for cancer and aging

To address this clinical need, we developed an assay to screen molecular libraries to identify novel hits that can inhibit the specific binding between Munc13-4 and STX7, two modulators of endolysosomal function necessary for eTLR activation