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Institute of Medicine, November 30, 2010

doi: 10.1039/D1CB00033K 169 PorterK.HoeyL.HughesC

Activation of IGF-IR/IRS complex also recruits and stimulates the PI3K, which converts PIP2 to PIP3 in the membrane to recruit Akt and associated proteins PDK 1/2, leading to Akt phosphorylation and activation