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Response to treatment varies considerably: Paraesthesia and early sensory symptoms often improve within weeks Cognitive and mood symptoms may take several months to resolve Established spinal cord damage (subacute combined degeneration) may show incomplete recovery, particularly if treatment was delayed Gait disturbances and proprioceptive loss may persist despite adequate treatment Monitoring during treatment should include clinical review of symptom progression and full blood count

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Researchers have proposed that BPC-157 may resist gastric acid due to its origin as a gastric protein fragment, but oral bioavailability figures have not been published for humans