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Description

Under physiological conditions, estrogen precisely regulates spermatogenesis and maintains the integrity of the blood-testis barrier (BTB) via its receptors (ER, ER, GPER) and epigenetic modifications (151153)

Therefore, it has been theorized that inhibition of xCT activities could promote Glu to replenish the TCA cycle intermediates, which could promote ROS production (102) ( Figure 4 )