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doi: 10.1002/j.1939-4640.2003.tb02641.x 163 FernandezJLMurielLGoyanesVSegrellesEGosalvezJEncisoMet al

In addition to cytochrome P450 enzymes, efflux transporters expressed at the bloodbrain barrier (BBB) critically shape central nervous system (CNS) exposure to psychotropic drugs (O'Brien et al., 2012a