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108 KuehneltD.JuresaD.KienzlN.FrancesconiK

Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis

In parallel with MTXs most well-known targets, several NAD+-dependent enzymes were inhibited by the antifolate in vitro : 2-oxoglutarate, isocitrate, malate, pyruvate, succinate, 6-phosphogluconate and glucose-6-phosphate dehydrogenases, glutamate-cysteine ligase, glutathione reductase, and glutathione peroxidase (29)