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Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

Saponins of tomato extract (STE), possessing potent free radical-scavenging capacity, have been shown to activate the AMPK signaling pathway, thereby suppressing downstream fatty acid synthesis-related proteins FAS and SCD1 to reduce fatty acid production and improve lipid metabolism, while simultaneously enhancing Nrf2 nuclear translocation to initiate transcription of antioxidant factors SOD and NQO1, ultimately mitigating XT301 high-fat diet-induced oxidative stress and hepatic oxidative damage

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