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Cell membranes are most vulnerable to lipid peroxidation due to their abundance of polyunsaturated fatty acids (PUFA)-containing phospholipids (PL)

When analyses were restricted to antidepressants primarily metabolized by CYP2C19 (such as citalopram, escitalopram, and sertraline), the same tendency persisted, supporting a pharmacokinetic contribution of CYP2C19 to antidepressant response, though statistical significance again was not achieved (Li et al., 2024)

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