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It can enhance energy production capacity by regulating nutrient intake and promoting fat oxidation through sensitization of brown adipose tissue ( 3.4 Clostridium in T1D T1D is a classic kind of AD ( According to the exploration results of the T1D patients or models, the following bacteria were mainly increased in abundance: Bifidobacterium longum ( Eubacterium rectale ( Bacteroides uniformis ( Lachnospira spp., Intestinimonas spp., Micrococcales spp ( Actinomyces spp ( Bacteroides spp ( Prevotella spp ( Ruminococcus spp ( Veillonella spp ( Lactococcus , Lactobacillus ( Streptococcus ( Bifidobacterium , Proteobacteria ( Subdoligranulum , Roseburia , Eubacterium , Anaerostipes ( FP ( Clostridium clusters IV ( XIVa ( Clostridium clusters IV/XIVa and butyrate-producing taxa is closely linked to impaired gut barrier function and -cell autoimmunity, laying the foundation for the core regulatory role of Clostridium and butyrate in T1D

Previous work highlighted the role of the cubilin receptor in intestinal vitamin B 12 absorption [27]

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