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A clinical trial investigating combinatorial use of intravaginal LACTIN-V (strain of Lactobacillus crispatus ) with metronidazole resulted in a 30% BV relapse rate 12 weeks post-treatment relative to a 45% relapse rate in the placebo group 112

Methods 18 , 507519 (2021)

This doesn't typically provide additive benefit and increases the risk of side effects like water retention, elevated IGF-1, and joint discomfort

Interestingly, Zackular and co-workers reported and hypothesized that Porphyromonadaceae may have an important protective role as anti-inflammatory mediators of gut health in a murine model of inflammation-driven colorectal cancer 22