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Oxidative modifications of lipids, proteins, and DNA are induced by mixtures of ascorbic acid and copper or iron for decades [24, 25], contributing to oxidative damage formation by reducing ferric Fe 3+ to ferrous Fe 2+ ions (and Cu 2+ to Cu + ), which in turn can reduce hydrogen peroxide (H 2 O 2 ) to hydroxyl radicals

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Note: Herbal supplements arent regulated as strictly as prescription medications, so their contents can vary widely

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Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

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Furthermore, one study suggests that neuronal stimulation, at least in the hippocampus, triggers neuronal glycolysis and the release of lactate from neurons (Zuend et al., 2020) or stimulation with cannabinoids (Jimenez-Blasco et al., 2020)

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