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Description

Smoother-looking texture, firmer-looking skin, or tolerance-first maintenance

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The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia

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The maintenance phase then requires 6 months to several years of therapy to prevent relapse and support continued recovery

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Phelps et al., 2011

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