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Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels

First, the VAT reduction was durable while treatment continued (about 18% sustained over 52 weeks, with parallel triglyceride improvement)

IGF-1 LR3 IGF-1 LR3 is a modified form of insulin-like growth factor-1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension, designed to have reduced binding to IGF-binding proteins, which increases its free, biologically active fraction and potency

Both stimulate natural growth hormone production, but they work through different pathways and produce different patterns of release