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P.BrouilletE.et al

Factors responsible for the liver's contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs

It belongs to the phenothiazinium class of dyes and exhibits a characteristic blue color in its oxidized form (Nedu et al

The assessment for liver transplantation in PBC is indicated when the patients show features of end-stage liver failure such as profound jaundice with or without intractable ascites, episodes of spontaneous bacterial peritonitis, and/or encephalopathy resistant to appropriate treatment, i.e