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Effects of natural polyphenols on oxidative stress-mediated blood-brain barrier dysfunction

Furthermore, the double mutant Asn240Thr/Leu244Arg was designed targeting the two activity controllers, which resembles the activity controller residues of cg AUS1(Thr253 and Arg257) 25

Its mechanism sits between tirzepatide and retatrutide in terms of receptor targets, offering a different balance of metabolic effects

Third, clinical translation should include establishing multicenter HD biobanks to validate associations between ferroptosis biomarkers (such as cerebrospinal fluid ACSL4 levels and striatal iron MRI signals) and clinical measures (UHDRS scores and transcranial motor-evoked potentials)