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By contrast, PRP and HA benefit from randomized human clinical data (knee osteoarthritis, tendinopathies) that the combo lacks

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The mature adipocytes secrete BMP4 that triggers preadipocyte differentiation by inducing the separation of Wnt1 inducible-signaling pathway protein 2 (WISP2) and zinc finger protein 423 (ZNF423), allowing ZNF423 to translocate into the nucleus and activate peroxisome proliferator-activated receptors (PPAR) and downstream cascade including CCAAT/enhancer-binding proteins (C/EBP), , and [41, 42] ( Figure 1 )

doi: 10.3390/nu12092867, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 10.Gulsen M, Yesilova Z, Bagci S, Uygun A, Ozcan A, Ercin CN, et al