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Embryofetal Toxicity Inform women that the incidence of congenital malformations (birth defects) after some Assisted Reproductive Technology [(ART) specifically in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI)] may be slightly higher than after spontaneous conception [see Warnings and Precautions (5.7)]

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Different insults induce brain tissue damage and lead to neuronal cell death such as ischemic injury, oxidative stress, and glutamate toxicity (Figure 4)