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Peptides remain an active area of interest and research with potential applications, but also with recognized need for careful consideration due to the variety of effects and potential risks

This comprehensive search utilized databases such as PubMed, Scopus, and Web of Science, with keywords including ME/CFS, Gut-Brain Axis, Gut Health, Intestinal Dysbiosis, Microbiome Dysbiosis, Pathophysiology, and Therapeutic Approaches. Where possible, insights from clinical trials and observational studies were included to enrich the findings

Critically, MC1R activation specifically drives eumelanin production, the darker and UV-absorbing form of melanin known to provides photoprotection

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