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Increased Sensitivity to Pollution and Environmental Stress People with adequate glutathione levels tend to be more resilient to environmental stressors

ROS causes renal vasoconstriction, sodium and volume retention, and induction of proinflammatory transcription components such as Nrf2, NFB, and AP110

Indeed, flavonoids have the well-known capacity to chelate several metal ions (such as iron and copper), blocking free radical generation (Kumar and Pandey, 2013)

Finally, the impact of ADPKD-related systemic abnormalities (e.g., electrolyte disturbances, hypertension, and liver cysts) on ferroptosis pathways and therapeutic responses is unexplored, which may affect the translatability of preclinical findings