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However, these compounds were not specifically designed to utilize LAT1 for brain delivery

For example, a meta-analysis of the effects of immune responses on oxidative status markers found that the effect size was always high in free-living birds, and more variable in captive birds 37

To overcome lower bioavailability as well as immune response issues, various delivery systems (encapsulation of ACPs in liposomes, polymer nanoparticles, or quantum dots) were used (186)