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Antineoplastics that are antimetabolites for the vitamin may induce inadequate utilization of vitamin B12

In these models, NNMT is often the culprit, and 5-Amino-1MQ offers a direct way to study the effects of inhibiting it

Several genes linked to vitiligo susceptibility related to immunomodulation of innate and adaptive immunity have also been identified (Tables 2 and 3)