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Springer International Publishing, Cham, pp 265273

This supercomplex in turn is thought to be activated by amino acids transported from the lysosomal lumen by transmembrane proteins, which in this way act as amino-acid sensors

MOTS-c activates AMPK pathways that improve GLUT4 glucose transport, restoring cellular glucose uptake without the GI side effects of metformin.5 For adults managing prediabetes or metabolic syndrome, this is clinically significant