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Mechanistic research has investigated GHK-Cu as a regulator of gene expression in dermal fibroblast research models, with broad effects observed across genes involved in extracellular matrix remodeling, copper homeostasis, antioxidant defense, and tissue signaling (Pickart & Margolina, 2018)

A yellow oval in Panel B indicates that the enzyme is affected by estradiol and/or testosterone, and therefore, its activity is different in females than males

10.1016/j.neuroscience.2018.09.033 Neuroscience 124 MetidjiA.OmenettiS.CrottaS.LiY.NyeE.RossE.et al (2018)

Wogonin and apigenin have been reported to ameliorate sepsis-induced ALI by regulating macrophage M1/M2 polarization (275, 276)