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Small amounts are manufactured in the gut, as long as horses are not under stress

The confirmed harms were a small increase in liver enzymes, a roughly 1% incidence of muscle symptoms, and a modest rise in blood sugar in patients already near the diabetes threshold

Conversely, poor or unhealthy diets significantly contribute to global mortality, with dietary risks identified as one of the leading risk factors for death and disability, accounting for 20% of the cases worldwide (47, 104)