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These findings reveal that HSC aging is a driver of aging-associated inflammation through maladaptive trained immunity and broaden the possible clinical applications of targeting HSCs from hematological diseases to include countering aging-associated physiological decline and improving healthspan

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doi: 10.3389/fphys.2023.1145216 Received 15 January 2023 Accepted 01 March 2023 Published 15 March 2023 Volume 14 - 2023 Edited by Deanne Helena Hryciw, Griffith University, Australia Reviewed by Marija Takic, Institute for Medical Research, University of Belgrade, Serbia Wei Zhang, Third Xiangya Hospital, Central South University, China Updates Copyright 2023 Baltusnikiene, Staneviciene and Jansen