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These are prescription medications requiring physician oversight, BMI eligibility criteria (typically 30 or 27 with comorbidities), and management of gastrointestinal side effects during dose escalation

Given that aging is associated with mitochondrial dysfunction and heightened oxidative stress, these effects may reflect a restoration of impaired adaptive signaling pathways rather than a purely ergogenic outcome

4 Hong JY, Park JS, Suh SW, Yang JH, Park SY, Kim BT

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