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Description

Cortisol, a hormone produced by the adrenal glands, can weaken collagen when levels are high for a prolonged period

On the other hand, the in vivo and in vitro models to study this mechanism are diverse, so it is difficult to draw a full picture of the progression of the events toward pancreatic beta-cell dysfunction

Immunoblotting Cells were lysed in protein lysis buffer (Cell Signaling) supplemented with Roche complete Protease Inhibitor Cocktail tablets (Sigma-aldrich)