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Stability of the glucuronides to b-glucuronidase e.g, Phenylbutazone, Ethclorvinyl UGT All glucuronides are cleaved by b-glucuronidase except C- glucuronides Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Two major human families of UGT - UGT1 and UGT2 From: Guillemette et al., Drug Metab Rev, 2010 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 UGT Structure and Homology Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Biochemical pathways for cosubstrate UDP-GA Glucose-1-P is derived from glycogen and the reactions are rapid, so co-substrate depletion not often observed unless in starved animals

Sensations obtained by centrifugation at 20,000 g, 20 min, and 4 were used for immunoblotting analysis

Increased lipophilicity of the drug may lead to enhanced plasma protein binding resulting in a diminished unbound plasma concentration of the drug (28)

Patients with mild jowls may only require one treatment, while those with moderate jowls may require at least two treatments