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Out of 1264 records initially retrieved, 38 RCTs were included

For instance, some patients report increased energy as their neurological function improvesthis is a therapeutic effect rather than a true adverse reaction

3 Natural products targeting tumor metabolism Although a variety of chemotherapeutic and molecularly targeted agents have been developed to inhibit key metabolic enzymes, their clinical application is often limited by modest efficacy, drug resistance, and severe adverse effects

For selectivity studies, recombinant GSTO1 (1 M), PDI (1 M), BSA (1 M) or GRP78 (1 M) in reaction buffer were incubated with C1-27 or DMSO for 30 min at 37 C, followed by incubation with CMFDA (500 nM), BODIPY- C1-27A (1 M) or DMSO for 30 min