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Microglia activation increases the amount of nuclear factor kappa-light-chain-enhancer of activated B-cells (NFKB) and NLR family pyrin domain-containing 3 (NLRP3), with subsequent upregulation of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and cytokines such as interleukin-1 beta (IL-1B) and tumor necrosis factor alpha (TNF) (53, 54)