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Therefore, these data provide direct evidence that mitochondrial oxidative catabolic activity causes ER stress

In their landmark 1973 paper, Lomo and Bliss recorded neuronal connection changes that were long-lasting and increased the strength of synaptic transmission, establishing the concept of LTP (Kandel et al., 1986), but in the 1990s pkc-mediated associative (conditioned) learning models were studied in both the marine sea snail Aplysia (Kruger et al., 1991) and the sea slug Hermissenda (Matzel et al., 1990