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RORt expressing innate like or Th lymphocytes promotes Type 3 immunity that produce the signature cytokines IL-17A and IL-17F

Although disorders of these enzymes are associated with a number of metabolic diseases, their function does not appear to be relevant for the red blood cell as these disorders are without hematologic consequences

doi: 10.1016/j.arr.2022.101735, 54

Key findings: Improved cardiovascular function and reduced atherosclerotic markers Restored circadian rhythm and melatonin secretion in elderly subjects Improved retinal function in patients with age-related retinal degeneration Enhanced immune function and T-cell activity Extended average lifespan in a 15-year follow-up study comparing treated vs