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In the SURMOUNT trials, night sweats were more common during dose escalation phases (when patients moved from 2.5 mg to 5 mg to 10 mg weekly injections) rather than at maintenance doses

Research has explored its role in cellular growth signaling, differentiation pathways, and IGF-1 receptor interaction mechanisms in laboratory models

Published mechanisms include upregulation of growth hormone receptor expression, promotion of angiogenesis via VEGF pathway activation, modulation of the nitric oxide system, and interaction with the dopaminergic and serotonergic systems in neurological models

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