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Thus, in this review we will discuss the involvement of Nrf2 in the mechanisms of action of classic analgesic and anti-inflammatory drugs, as well as natural products and other molecules that modulate Nrf2, in the context of experimental models (summarized in Table 1) and human diseases (summarized in Table 2)

This resulted in adjusted causal estimates after identifying and excluding outlier instruments (Verbanck et al., 2018)